To explore or attempt something that has never been done before.
これまで誰も行ったことのないことを探検または試みること。 (kore made daremo itta koto no nai koto o tanken mata wa kokoromiru koto)
"The mission to Mars aims to go where no man has gone before."
"火星へのミッションは、誰も行ったことのない場所に行くことを目指している。" (kasei e no misshon wa daremo itta koto no nai basho ni iku koto o mezashite iru)
used to say that an activity has been successful up to this...
not under one’s power or influence
to repair a relationship
to be extremely frustrated and have no patience left
to do exactly what is needed to get a desired result
working late into the night