despite great difficulties or challenges
大きな困難にもかかわらず (ookina konnan ni mo kakawarazu)
"She succeeded against all odds and became a doctor."
"彼女はあらゆる困難を乗り越えて医者になった。" (kanojo wa arayuru konnan o norikoete isha ni natta)
A strong and reliable base or starting point.
naturally designed to acquire knowledge or skills
to cry a lot; to weep uncontrollably
being considered for elimination or discontinuation
to begin something well or positively
to amaze or astonish someone greatly
