to be in charge of or accountable for something
何かに対して責任を持つ (nanika ni taishite sekinin o motsu)
"She is responsible for managing the entire department."
"彼女は全ての部署を管理する責任を負っています。" (Kanojo wa subete no busho o kanri suru sekinin o motteimasu.)
having lived a long and fulfilling life
to change your opinion or the way you feel about something
to cause good fortune
to stop believing in your own ability or someone else’s
after a long time; in the end
to feel very good or confident