to make a significant discovery or achievement
сделать значительное открытие или достижение (sdelat' znachitel'noe otkrytie ili dostizhenie)
"She made a breakthrough in her research that could change the field."
"Она сделала прорыв в своем исследовании, которое может изменить эту область." (ona sdelala proryv v svoem issledovanii, kotoroe mozhet izmenit' etu oblast')
to deal with a problem when it happens, not before
to end something dramatically
to be in charge and make decisions
to be free from blame or responsibility for something
A strong and reliable base or starting point.
you can’t achieve anything if you don’t take risks