In a situation that is unknown or unfamiliar.
В неизвестной или незнакомой ситуации. (v neizvestnoi ili neznakomoi situatsii)
"The astronauts are heading into uncharted waters as they explore the unknown galaxy."
"Космонавты направляются в неизведанные воды, исследуя неизвестную галактику." (kosmonavty napravlyayutsya v neizvedannye vody issleduya neizvestnuyu galaktiku)
to irritate or annoy someone without intending to
An undocumented way of accessing a system or software, usual...
to become less angry or upset
a connected series of thoughts
to reach the highest point of success
to earn a lot of money