to work hard and continuously
travailler dur et continuellement (travailler dur et continuellement)
"If you keep your nose to the grindstone, you’ll achieve your goals."
"Si vous gardez votre nez sur la meule, vous atteindrez vos objectifs." (si vous gardez votre nez sur la meule, vous atteindrez vos objectifs)
at the most advanced position in a field
to continue working even when you are tired or out of energy
to reach the lowest point of failure or depression
to feel intense fear or horror
to continue to hope or work toward a goal even after setback...
to reduce differences or improve relations